Drug Information

Drug General Information
Drug ID
D0AV0O
Former ID
DIB009884
Drug Name
OPC-51803
Synonyms
SOU-003; 2-[1-[2-Chloro-4-(1-pyrrolidinyl)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepin-5(R)-yl]-N-isopropylacetamide
Drug Type
Small molecular drug
Indication Urinary incontinence [ICD9: 788.3; ICD10:N39.3, N39.4, R32] Discontinued in Phase 1 [539376], [546847]
Company
Otsuka America Pharmaceutical; Sosei
Structure
Download
2D MOL

3D MOL
Formula
C26H32ClN3O2
InChI
InChI=1S/C26H32ClN3O2/c1-18(2)28-25(31)16-19-8-7-15-30(24-10-4-3-9-21(19)24)26(32)22-12-11-20(17-23(22)27)29-13-5-6-14-29/h3-4,9-12,17-19H,5-8,13-16H2,1-2H3,(H,28,31)/t19-/m1/s1
InChIKey
INGXCNVWWKKWOO-LJQANCHMSA-N
CAS Number
CAS 192514-54-8
PubChem Compound ID
3038506
PubChem Substance ID
7980204, 10049042, 12015228, 14906675, 36106219, 78832190, 103355871, 104011042, 111646241, 128192508, 135141706, 135650776, 138069833, 140436589, 175427043, 225071531, 228106159
Target and Pathway
Target(s) Vasopressin V2 receptor Target Info Agonist [526938]
KEGG Pathway Neuroactive ligand-receptor interaction
Vasopressin-regulated water reabsorption
Pathway Interaction Database Arf6 trafficking events
PathWhiz Pathway Vasopressin Regulation of Water Homeostasis
Reactome Vasopressin-like receptors
G alpha (s) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
WikiPathways GPCRs, Class A Rhodopsin-like
Regulation of Water Balance by Renal Aquaporins
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539376(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2173).
Ref 546847Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010599)
Ref 526938Effects of OPC-51803, a novel, nonpeptide vasopressin V2-receptor agonist, on micturition frequency in Brattleboro and aged rats. J Pharmacol Sci. 2003 Dec;93(4):484-8.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.