Drug Information

Drug General Information
Drug ID
D0Y1FO
Former ID
DIB008120
Drug Name
Rubitecan
Synonyms
Inhaled Orathecin; L9NC; Rubitecan (inhaled); Aerosolized liposomal 9 nitro-20 (S) camptothecin; Rubitecan (inhaled), SuperGen; 9-Nitro-20(S)-camptothecin
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Phase 3 [521474]
Company
SuperGen; Clayton Foundation For Research; MD Anderson Cancer Center
Structure
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2D MOL

3D MOL
Formula
C20H15N3O6
Canonical SMILES
n12c(c3c(C2)cc2c([N+](=O)[O-])cccc2n3)cc2c(c1=O)COC(=O)<br />[C@]2(O)CC
CAS Number
CAS 91421-42-0
PubChem Compound ID
472335
Target and Pathway
Target(s) Toposisomerase-1 Target Info Inhibitor [527937]
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway DNA replication
Pathway Interaction Database Caspase Cascade in Apoptosis
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 521474ClinicalTrials.gov (NCT00005869) Nitrocamptothecin Compared With Gemcitabine in Treating Patients With Unresectable Locally Advanced or Metastatic Pancreatic Cancer. U.S. National Institutes of Health.
Ref 527937Rubitecan. Expert Opin Investig Drugs. 2006 Jan;15(1):71-9.

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