Drug General Information
Drug ID	D00OVC
Former ID	DIB016808
Drug Name	EVT-201
Synonyms	IDDBCP221837
Indication	Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10:F51.0, G47.0]		Phase 2	[521889]
Company	Roche Holding AG
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c12c(c3nc(on3)CN(C)C)ncn1c1c(C(=O)N(C2)C)c(Cl)ccc1
Target and Pathway
Target(s)	GABA A receptor	Target Info	Modulator	[543814]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 521889	ClinicalTrials.gov (NCT00380003) Efficacy Study of EVT 201 to Treat Insomnia. U.S. National Institutes of Health.
Ref 543814	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).

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