Drug General Information
Drug ID	D00LHF
Former ID	DIB012710
Drug Name	GS-9219
Synonyms	PMEG prodrug (cancer), Gilead
Drug Type	Small molecular drug
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Phase 1/2	[522061]
Company	Gilead Sciences Inc
Structure		Download 2D MOL 3D MOL
Formula	C21H35N8O6P
Canonical SMILES	P(=O)(N[C@H](C(=O)OCC)C)(COCCn1cnc2c1nc(nc2NC1CC1)N)N[C<br />@H](C(=O)OCC)C
PubChem Compound ID	16047979
Target and Pathway
Target(s)	DNA polymerase	Target Info	Inhibitor	[529449]
References
Ref 522061	ClinicalTrials.gov (NCT00499239) A Trial of GS-9219 in Chronic Lymphocytic Leukemia (CLL), Non-Hodgkin's Lymphoma (NHL) or Multiple Myeloma (MM). U.S. National Institutes of Health.
Ref 529449	GS-9219--a novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma. Clin Cancer Res. 2008 May 1;14(9):2824-32.

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