Drug Information

Drug General Information
Drug ID
D0L1DP
Former ID
DCL000675
Drug Name
ABT-089
Synonyms
Pozanicline; A 94224; ABT 089; Pozanicline (USAN); (R)-2-Methyl-3-(2-pyrrolidinylmethoxy)pyridine; 2-Methyl-3-(2-pyrrolidinylmethoxy)pyridine; 2-Methyl-3-(2S-pyrrolidinylmethoxy)pyridine; 2-methyl-3-[[(2R)-pyrrolidin-2-yl]methoxy]pyridine; 2-methyl-3-[[(2S)-pyrrolidin-2-yl]methoxy]pyridine
Drug Type
Small molecular drug
Indication Attention deficit hyperactivity disorder; Schizophrenia; Anxiety; Dementia [ICD9: 290-294, 295, 300, 314.0; ICD10:F01-F07, F20, F40-F42, F90] Discontinued in Phase 2 [536499]
Company
Abbott Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C11H16N2O
Canonical SMILES
CC1=C(C=CC=N1)OCC2CCCN2
InChI
1S/C11H16N2O/c1-9-11(5-3-6-12-9)14-8-10-4-2-7-13-10/h3,5-6,10,13H,2,4,7-8H2,1H3/t10-/m0/s1
InChIKey
YRVIKLBSVVNSHF-JTQLQIEISA-N
CAS Number
CAS 161417-03-4
PubChem Compound ID
178052
PubChem Substance ID
10258848, 15120824, 33501377, 48105232, 48329093, 78076924, 96026047, 103358844, 103952511, 104426892, 129839005, 134339192, 135156012, 137143666, 139821197, 162219917, 162799159, 163563861, 175427009, 198983979, 225054926, 226552961
Target and Pathway
Target(s) Nicotinic ACh receptor alpha 4/beta 2 Target Info Modulator
References
Ref 536499Emerging drugs for attention-deficit/hyperactivity disorder. Expert Opin Emerg Drugs. 2007 Sep;12(3):423-34.

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