Drug Information

Drug General Information
Drug ID
D06SAT
Former ID
DIB002839
Drug Name
HZ-166
Synonyms
Benzodiazepine derivatives (neuropathic pain); HZ-166; Benzodiazepine derivatives (neuropathic pain), Addiction Therapeutix
Indication Neuropathic pain [ICD9: 356.0, 356.8; ICD10:G64, G90.0] Investigative [543814]
Company
University of Wisconsin-Milwaukee
Structure
Download
2D MOL

3D MOL
Canonical SMILES
c1c(cc2c(c1)n1c(CN=C2c2ccccn2)c(nc1)C(=O)OCC)C#C
Target and Pathway
Target(s) GABA A receptor Target Info Modulator [543814]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 543814(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).
Ref 543814(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).

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