Drug Information

Drug General Information
Drug ID
D02MXT
Former ID
DIB013268
Drug Name
MK-2894
Synonyms
EP4 antagonists (inflammatory pain); L-161982; MF-310; MF-498; MF-592; MF-766; MK-2894; EP4 antagonists (inflammatory pain), Merck Frosst Canada; Prostaglandin E2 subtype 4 receptor antagonists (pain/inflammation), Merck Frosst
Drug Type
Small molecular drug
Indication Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] Investigative [541165]
Company
Merck Frosst Canada & Co
Structure
Download
2D MOL

3D MOL
Formula
C25H22F3NO3S
InChI
InChI=1S/C25H22F3NO3S/c1-14-20(13-16-3-7-19(8-4-16)25(26,27)28)21(15(2)33-14)22(30)29-24(11-12-24)18-9-5-17(6-10-18)23(31)32/h3-10H,11-13H2,1-2H3,(H,29,30)(H,31,32)
InChIKey
QJZQFVRFJCGDKF-UHFFFAOYSA-N
PubChem Compound ID
24952929
PubChem Substance ID
56250754, 57482598, 103723003, 104162492, 137908617, 141023643, 152258207, 160647043, 178100865, 185964355, 224315310, 228469898, 245762535, 251963161, 252479802
Target and Pathway
Target(s) Prostaglandin E2 receptor, EP4 subtype Target Info Antagonist [543780]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancer
NetPath Pathway FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 541165(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5856).
Ref 543780(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 343).

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