Drug General Information
Drug ID	D01ERN
Former ID	DIB006555
Drug Name	MGluR5 antagonists (anxiety), Novartis
Synonyms	MGluR5 antagonists (anxiety); MGluR5 antagonists (anxiety), Novartis
Indication	Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]		Investigative	[543750]
Company	Novartis AG
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(=O)(N1C(CCCC1)CC)c1cnc(c(c1)Cl)Nc1cnc(cc1)C
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Antagonist	[543750]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 543750	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 293).
Ref 543750	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 293).

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