Drug Information

Drug General Information
Drug ID
D0J8NC
Former ID
DIB014636
Drug Name
ASP-8370
Synonyms
AS-1725195; AS-1928370; ASP-8370; TRPV1 antagonists (neuropathic pain); TRPV1 antagonists (neuropathic pain), Astellas
Indication Neuropathic pain [ICD9: 356.0, 356.8; ICD10:G64, G90.0] Investigative [543861]
Company
Astellas Pharma Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
c1(c(cc(cc1)C(=O)Nc1ccc2c(c1)NC(=O)[C@H](O2)C)CN1CCCCC1<br />)c1ccccc1.Cl
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Antagonist [543861]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 543861(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507).
Ref 543861(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507).

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