Drug Information

Drug General Information
Drug ID
D00CKQ
Former ID
DIB012972
Drug Name
TRPV1 antagonists
Synonyms
TRPV1 antagonists (pain); TRPV1 antagonists (pain), Merck & Co; TRPV1 antagonists (pain), Schering-Plough; Transient receptor potential vanilloid receptor-1 antagonists (pain), Merck & Co; Transient receptor potential vanilloid receptor-1 antagonists (pain), Schering-Plough
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Investigative [552032]
Company
Schering-Plough Corp
Structure
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2D MOL

3D MOL
Canonical SMILES
c1(ccc(cc1)C(F)(F)F)c1onc(c1CNCC(C)C)C(=O)N[C@H]1C[C@H]<br />(CCC1)O
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Antagonist [543861]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 552032TRPV1 antagonists as potential antitussive agents. Lung. 2008;186 Suppl 1:S59-65. Epub 2007 Oct 10.
Ref 543861(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507).

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