Drug Information

Drug General Information
Drug ID
D01KCF
Former ID
DIB016474
Drug Name
Small molecule 2a
Synonyms
Vasopressin V1b receptor antagonists (depression); Vasopressin V1b receptor antagonists (depression), GlaxoSmithKline
Indication Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Investigative [543797]
Company
GlaxoSmithKline plc
Structure
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2D MOL

3D MOL
Canonical SMILES
O=S(=O)(c1ccc(cc1)OC)N(Cc1nc(sc1)c1ccc(cc1)CNCCCC)C1CCO<br />CC1
Target and Pathway
Target(s) Vasopressin V1b receptor Target Info Antagonist [543797]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Reactome Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543797(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 367).
Ref 543797(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 367).

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