TTD | Drug: D06SUS

Drug General Information
Drug ID	D06SUS
Former ID	DIB005204
Drug Name	AZD-3043
Synonyms	TD-4756; THRX-918661
Drug Type	Small molecular drug
Indication	Anesthesia [ICD9: 338; ICD10:R20.0]		Phase 1	[522974]
Company	Theravance Inc
Structure		Download 2D MOL 3D MOL
Formula	C19H29NO5
Canonical SMILES	CCCOC(=O)CC1=CC(=C(C=C1)OCC(=O)N(CC)CC)OCC
InChI	1S/C19H29NO5/c1-5-11-24-19(22)13-15-9-10-16(17(12-15)23-8-4)25-14-18(21)20(6-2)7-3/h9-10,12H,5-8,11,13-14H2,1-4H3
InChIKey	QPUVKSKJCNGSGT-UHFFFAOYSA-N
PubChem Compound ID	10286834
PubChem Substance ID	15292784, 22662557, 35558829, 77739568, 142689314, 172650195, 198964425, 228051940, 245402270, 249755324
Target and Pathway
Target(s)	GABA A receptor	Target Info	Modulator	[531883]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
Reactome	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 522974	ClinicalTrials.gov (NCT01086813) Phase I, Single Centre, Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD3043. U.S. National Institutes of Health.
Ref 531883	AZD-3043: a novel, metabolically labile sedative-hypnotic agent with rapid and predictable emergence from hypnosis. Anesthesiology. 2012 Jun;116(6):1267-77.

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Drug Information