Drug Information

Drug General Information
Drug ID
D04YEY
Former ID
DIB000237
Drug Name
PS-388023
Synonyms
PS-680648; PS-780035; Angiogenesis inhibitors (ocular indications), Pharmacopeia/Allergan; Angiogenesis inhibitors (inflammatory/ocular/oncological indications), Pharmacopeia; Dual integrin avb3/avb5 inhibitors (inflammatory/ocular/oncological indications), Pharmacopeia; Dual integrin alpha-5/beta-3 + alpha-5/beta-5 inhibitors (inflammatory/ocular/oncological indications), Pharmacopeia
Indication Ocular disease [ICD10:H00-H59] Terminated [548165]
Company
Pharmacopeia Inc
Target and Pathway
Target(s) Integrin alpha-V/beta-3 Target Info Modulator [556264]
Integrin alpha-V/beta-5 Target Info Modulator [556264]
Reactome Cross-presentation of particulate exogenous antigens (phagosomes)
Elastic fibre formation
Molecules associated with elastic fibres
Integrin cell surface interactions
Laminin interactions
Syndecan interactions
ECM proteoglycans
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
WikiPathways Osteoblast Signaling
Focal Adhesion
Class I MHC mediated antigen processing & presentation
Syndecan interactions
Extracellular matrix organization
Elastic fibre formation
Primary Focal Segmental Glomerulosclerosis FSGS
Arrhythmogenic Right Ventricular Cardiomyopathy
Integrin-mediated Cell Adhesion
L1CAM interactions
Integrin cell surface interactions
Cell surface interactions at the vascular wall
Osteopontin Signaling
References
Ref 548165Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022665)
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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