Drug Information

Drug General Information
Drug ID
D05LOV
Former ID
DIB004069
Drug Name
ADV-1002401
Synonyms
GKM-001; Hypoglycemic agent (diabetes), Advinus
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Phase 1 [549053]
Company
Advinus Therapeutics
Target and Pathway
Target(s) Glucokinase Target Info Inhibitor [544410]
KEGG Pathway Glycolysis / Gluconeogenesis
Galactose metabolism
Starch and sucrose metabolism
Amino sugar and nucleotide sugar metabolism
Butirosin and neomycin biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Carbon metabolism
Insulin signaling pathway
Insulin secretion
Prolactin signaling pathway
Glucagon signaling pathway
Type II diabetes mellitus
Maturity onset diabetes of the young
Central carbon metabolism in cancer
Pathway Interaction Database FOXA2 and FOXA3 transcription factor networks
HIF-1-alpha transcription factor network
PathWhiz Pathway Nucleotide Sugars Metabolism
Starch and Sucrose Metabolism
Galactose Metabolism
Trehalose Degradation
Reactome Regulation of gene expression in beta cells
Glucose transport
Glycolysis
WikiPathways SIDS Susceptibility Pathways
Glycolysis and Gluconeogenesis
MAPK Signaling Pathway
Regulation of beta-cell development
Metabolism of carbohydrates
Hexose transport
References
Ref 549053Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031821)
Ref 544410The Hepatoselective Glucokinase Activator PF-04991532 Ameliorates Hyperglycemia without Causing Hepatic Steatosis in Diabetic Rats. PLoS One. 2014; 9(5): e97139.

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