Drug Information

Drug General Information
Drug ID
D0U5CE
Former ID
DIB015944
Drug Name
Capsaicin
Synonyms
Capsaicin (transdermal patch formulation, neuropathic pain)
Drug Type
Small molecular drug
Indication Neuropathic pain [ICD9: 356.0, 356.8; ICD10:G64, G90.0] Approved [522464], [539611]
Company
Samyang Corp
Structure
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2D MOL

3D MOL
Formula
C18H27NO3
InChI
InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
InChIKey
YKPUWZUDDOIDPM-SOFGYWHQSA-N
PubChem Compound ID
1548943
PubChem Substance ID
9083, 105773, 853800, 1916595, 7847316, 7978850, 8149724, 8653307, 10321304, 11537699, 12015395, 14923155, 17389996, 17486482, 22391501, 24847432, 24853014, 24853015, 24862158, 24896598, 26612181, 26680132, 26681474, 26744231, 26747263, 26747264, 26752818, 26752819, 26752820, 26758379, 29203915, 32248886, 46487934, 47216576, 47364983, 47515116, 47662075, 47662076, 47736251, 47736252, 47810544, 47885207, 48034884, 48259019, 48413373, 48423080, 48424925, 49688535, 49698675, 49747048
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Agonist [528612], [529267]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 522464ClinicalTrials.gov (NCT00771511) Cervical Capsaicin for Labor Induction and Pain Relief. U.S. National Institutes of Health.
Ref 539611(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2486).
Ref 528612Capsaicin receptor: TRPV1 a promiscuous TRP channel. Handb Exp Pharmacol. 2007;(179):155-71.
Ref 529267Capsaicin (TRPV1 Agonist) therapy for pain relief: farewell or revival. Clin J Pain. 2008 Feb;24(2):142-54.

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