Drug Information

Drug General Information
Drug ID
D0XD5A
Former ID
DIB006360
Drug Name
E-101
Synonyms
Myeloperoxidase; Glucose oxidase; Human myeloperoxidase, dimer; E-101 (infections); Myeloperoxidase formulations (nosocomial infections), Exoxemis; E-101 (infections), Exoxemis; MPO enzyme system (hospital-acquiredl infections), Exoxemis; Myeloperoxidase + glucose oxidase (infections), Exoxemis
Drug Type
Small molecular drug
Indication Infections disease [ICD10:A00-B99] Phase 3 [523361]
Company
Exoxemis
Structure
Download
2D MOL
Formula
C17H26Cl2N2O3
PubChem Compound ID
11973707
Target and Pathway
Target(s) Myeloperoxidase Target Info Modulator [531278]
KEGG Pathway Phagosome
Transcriptional misregulation in cancer
Pathway Interaction Database C-MYB transcription factor network
IL23-mediated signaling events
WikiPathways Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 523361ClinicalTrials.gov (NCT01297959) Efficacy and Safety of E-101 Solution for Preventing Surgical Site Infections After Colorectal Surgery. U.S. National Institutes of Health.
Ref 531278In vitro antibacterial activity of E-101 Solution, a novel myeloperoxidase-mediated antimicrobial, against Gram-positive and Gram-negative pathogens. J Antimicrob Chemother. 2011 Feb;66(2):335-42.

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