Drug Information

Drug General Information
Drug ID
D0Y0BC
Former ID
DIB012577
Drug Name
XL-541
Synonyms
S1P1R antagonists (oral, cancer), Exelixis
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Terminated [548837]
Company
Exelixis Inc
Target and Pathway
Target(s) Sphingosine 1-phosphate receptor 1 Target Info Antagonist [531753]
KEGG Pathway FoxO signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
S1P3 pathway
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathway
Reactome G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 548837Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029368)
Ref 531753Discovery of a novel class of potent and orally bioavailable sphingosine 1-phosphate receptor 1 antagonists. J Med Chem. 2012 Feb 9;55(3):1368-81.

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