| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T38875 | ||||
| Target Name | AMP-activated protein kinase | ||||
| Target Type | Clinical Trial |
||||
| Drug Potency against Target | SU 6656 | Drug Info | IC50 = 110 nM | [529039] | |
| 4-(3-bromopyrazolo[1,5-a]pyrimidin-6-yl)phenol | Drug Info | IC50 = 7700 nM | [531199] | ||
| DORSOMORPHIN | Drug Info | IC50 = 41 nM | [531199] | ||
| References | |||||
| Ref 529039 | Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update. | ||||
| Ref 531199 | Bioorg Med Chem Lett. 2010 Nov 15;20(22):6394-9. Epub 2010 Sep 19.The rational design of a novel potent analogue of the 5'-AMP-activated protein kinase inhibitor compound C with improved selectivityand cellular activity. | ||||
| Ref 531199 | Bioorg Med Chem Lett. 2010 Nov 15;20(22):6394-9. Epub 2010 Sep 19.The rational design of a novel potent analogue of the 5'-AMP-activated protein kinase inhibitor compound C with improved selectivityand cellular activity. | ||||
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