Target Validation Information
Target ID T45993
Target Name Calcium channel
Target Type
Successful
Drug Potency against Target Nisoldipine Drug Info IC50 = 80 nM [552383]
Felodipine Drug Info IC50 = 1.45 nM [553239]
Nicardipine Drug Info Ki = 280 nM [552597]
Nimodipine Drug Info IC50 = 14.9 nM [553239]
References
Ref 552383Block of cardiac delayed-rectifier and inward-rectifier K+ currents by nisoldipine. Br J Pharmacol. 2003 Nov;140(5):863-70. Epub 2003 Oct 6.
Ref 553239Synthesis, biological evaluation, calcium channel antagonist activity, and anticonvulsant activity of felodipine coupled to a dihydropyridine-pyridinium salt redox chemical delivery system. J Med Chem. 1996 Nov 8;39(23):4576-82.
Ref 552597Development and validation of an in silico P450 profiler based on pharmacophore models. Curr Drug Discov Technol. 2006 Mar;3(1):1-48.
Ref 553239Synthesis, biological evaluation, calcium channel antagonist activity, and anticonvulsant activity of felodipine coupled to a dihydropyridine-pyridinium salt redox chemical delivery system. J Med Chem. 1996 Nov 8;39(23):4576-82.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.