Target Validation Information
Target ID T35940
Target Name Dual specificity mitogen-activated protein kinase kinase 1
Target Type
Discontinued
Drug Potency against Target 4,5-Dibromo-1H-pyrrole-2-carboxylic acid amide Drug Info IC50 = 2500 nM [526243]
REVERSINE Drug Info IC50 = 8 nM [528890]
5-phenylamino-4-cyano-3-hydroxy-isothiazole Drug Info IC50 = 7000 nM [528219]
ALDISIN Drug Info IC50 = 2500 nM [526243]
OROIDIN Drug Info IC50 = 2500 nM [526243]
DEBROMOHYMENIALDISINE Drug Info IC50 = 2500 nM [526243]
References
Ref 526243J Med Chem. 2002 Jan 17;45(2):529-32.Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).
Ref 528890Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10482-7. Epub 2007 Jun 12.Reversine increases the plasticity of lineage-committed mammalian cells.
Ref 528219Bioorg Med Chem Lett. 2006 Aug 1;16(15):3975-80. Epub 2006 May 24.Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors.
Ref 526243J Med Chem. 2002 Jan 17;45(2):529-32.Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).
Ref 526243J Med Chem. 2002 Jan 17;45(2):529-32.Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).
Ref 526243J Med Chem. 2002 Jan 17;45(2):529-32.Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).

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