Target Validation Information
Target ID T50269
Target Name Glycine receptor alpha-1 chain
Target Type
Successful
Drug Potency against Target Ginkgolide M Drug Info IC50 = 650 nM [528727]
THIOCOLCHICOSIDE Drug Info IC50 = 1500 nM [528408]
3-demethoxy-3-D-mannopyranosylaminothiocolchicine Drug Info IC50 = 13100 nM [528408]
GINKOLIDE B Drug Info IC50 = 1700 nM [528727]
10-methoxy-ginkgolide C Drug Info IC50 = 5200 nM [528727]
GINKGOLIDE A Drug Info IC50 = 3800 nM [528727]
3-demethoxy-3-D-lyxopyranosylaminothiocolchicine Drug Info IC50 = 4100 nM [528408]
STRYCHNINE Drug Info IC50 = 14 nM [528408]
3-demethoxy-3-D-xylopyranosylaminothiocolchicine Drug Info IC50 = 3300 nM [528408]
3,14-DIDEHYDROGINKGOLIDE A Drug Info IC50 = 3100 nM [528727]
Ginkgolide J Drug Info IC50 = 6400 nM [528727]
Ginkgolide C Drug Info IC50 = 5900 nM [528727]
3-demethoxy-3D-glucopyranosylaminothiocolchicine Drug Info IC50 = 10600 nM [528408]
3-demethoxy-3-L-fucopyranosylaminothiocolchicine Drug Info IC50 = 4200 nM [528408]
References
Ref 528727J Med Chem. 2007 Apr 5;50(7):1610-7. Epub 2007 Mar 13.Probing the pharmacophore of ginkgolides as glycine receptor antagonists.
Ref 528408J Med Chem. 2006 Sep 7;49(18):5571-7.3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds.
Ref 528408J Med Chem. 2006 Sep 7;49(18):5571-7.3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds.
Ref 528727J Med Chem. 2007 Apr 5;50(7):1610-7. Epub 2007 Mar 13.Probing the pharmacophore of ginkgolides as glycine receptor antagonists.
Ref 528727J Med Chem. 2007 Apr 5;50(7):1610-7. Epub 2007 Mar 13.Probing the pharmacophore of ginkgolides as glycine receptor antagonists.
Ref 528727J Med Chem. 2007 Apr 5;50(7):1610-7. Epub 2007 Mar 13.Probing the pharmacophore of ginkgolides as glycine receptor antagonists.
Ref 528408J Med Chem. 2006 Sep 7;49(18):5571-7.3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds.
Ref 528408J Med Chem. 2006 Sep 7;49(18):5571-7.3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds.
Ref 528408J Med Chem. 2006 Sep 7;49(18):5571-7.3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds.
Ref 528727J Med Chem. 2007 Apr 5;50(7):1610-7. Epub 2007 Mar 13.Probing the pharmacophore of ginkgolides as glycine receptor antagonists.
Ref 528727J Med Chem. 2007 Apr 5;50(7):1610-7. Epub 2007 Mar 13.Probing the pharmacophore of ginkgolides as glycine receptor antagonists.
Ref 528727J Med Chem. 2007 Apr 5;50(7):1610-7. Epub 2007 Mar 13.Probing the pharmacophore of ginkgolides as glycine receptor antagonists.
Ref 528408J Med Chem. 2006 Sep 7;49(18):5571-7.3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds.
Ref 528408J Med Chem. 2006 Sep 7;49(18):5571-7.3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds.

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