| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T67102 | ||||
| Target Name | Cathepsin D | ||||
| Target Type | Clinical Trial |
||||
| Drug Potency against Target | GRL-7234 | Drug Info | Ki = 41 nM | [528786] | |
| GRASSYSTATIN A | Drug Info | IC50 = 1000 nM | [530345] | ||
| CI-992 | Drug Info | IC50 = 1250 nM | [527925] | ||
| KNI-10006 | Drug Info | Ki = 2 nM | [530280] | ||
| References | |||||
| Ref 528786 | J Med Chem. 2007 May 17;50(10):2399-407. Epub 2007 Apr 14.Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands. | ||||
| Ref 530345 | J Med Chem. 2009 Sep 24;52(18):5732-47.Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. | ||||
| Ref 527925 | J Med Chem. 1992 Jul 10;35(14):2562-72.Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors. | ||||
| Ref 530280 | Bioorg Med Chem. 2009 Aug 15;17(16):5933-49. Epub 2009 Jul 3.alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases. | ||||
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