Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T77548 | ||||
Target Name | Metabotropic glutamate receptor 8 | ||||
Target Type | Research |
||||
Drug Potency against Target | L-1-amino-4-phosphonobutanoic acid | Drug Info | Ki = 1900 nM | [528723] | |
GLUTAMATE | Drug Info | Ki = 3400 nM | [528723] | ||
QUISQUALATE | Drug Info | IC50 = 25 nM | [534590] | ||
2-Amino-4-phosphono-butyric acid | Drug Info | IC50 = 5.1 nM | [527336] | ||
References | |||||
Ref 528723 | Bioorg Med Chem. 2007 May 1;15(9):3161-70. Epub 2007 Feb 22.Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines. | ||||
Ref 528723 | Bioorg Med Chem. 2007 May 1;15(9):3161-70. Epub 2007 Feb 22.Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines. | ||||
Ref 534590 | J Med Chem. 1998 Mar 12;41(6):930-9.Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid. | ||||
Ref 527336 | Bioorg Med Chem Lett. 2005 Jan 17;15(2):349-51.(2S,1'S,2'R,3'R)-2(2'-Carboxy-3'-hydroxymethylcyclopropyl)glycine-[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic glutamate receptors. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.