Target General Information
Target ID T03644
Target Name Alpha-synuclein
Synonyms NACP; NonA beta component of AD amyloid; NonA4 component of amyloid precursor; SNCA
Target Type Clinical Trial
Gene Name SNCA
Biochemical Class Synuclein family
UniProt ID SYUA_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Alzheimer's disease
Example drug Posiphen R-phenserine Phase 1 [550986], [1572592]
Tissue Entorhinal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.64
Z-score: -0.92
P-value: 7.86E-08
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Parkinson's disease
Example drug RG7935 Phase 1 [549547], [1572592]
Tissue Substantia nigra tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.26
Z-score: -0.33
P-value: 1.04E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 549547Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040327)
Ref 550986The Anticholinesterase Phenserine and Its Enantiomer Posiphen as 5??ntranslated-Region-Directed Translation Blockers of the Parkinson's Alpha Synuclein Expression. Parkinson's Disease Volume 2012 (2012), Article ID 142372, Page(13).
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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