Target expression details
Target General Information | |||||
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Target ID | T03644 | ||||
Target Name | Alpha-synuclein | ||||
Synonyms | NACP; NonA beta component of AD amyloid; NonA4 component of amyloid precursor; SNCA | ||||
Target Type | Clinical Trial | ||||
Gene Name | SNCA | ||||
Biochemical Class | Synuclein family | ||||
UniProt ID | SYUA_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Alzheimer's disease | ||||
Example drug | Posiphen R-phenserine | Phase 1 | [550986], [1572592] | ||
Tissue | Entorhinal cortex | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.64 Z-score: -0.92 P-value: 7.86E-08 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Parkinson's disease | ||||
Example drug | RG7935 | Phase 1 | [549547], [1572592] | ||
Tissue | Substantia nigra tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.26 Z-score: -0.33 P-value: 1.04E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
Reference | |||||
Ref 549547 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040327) |
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