Target General Information
Target ID T10482
Target Name mRNA of factor XII
Synonyms Coagulation factor XII (mRNA); Coagulation factor XIIa light chain (mRNA); F12 (mRNA); HAF (mRNA); Hageman factor (mRNA); F12
Target Type Clinical Trial
Gene Name F12
Biochemical Class Peptidase
UniProt ID FA12_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Alzheimer's disease
Example drug methyl 5-[(4-tert-butylbenzoyl)amino]-2H-1,2,4-triazole-3-carboxylate Clinical trial [541677], [1572592]
Tissue Entorhinal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.34
Z-score: -0.63
P-value: 1.43E-07
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 541677(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6553).
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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