Target General Information
Target ID	T10897
Target Name	Acyl-CoA desaturase
Synonyms	9 stearoyl-desaturase; Delta(9)-desaturase; Delta-9-stearoyl desaturase; Des A3; DesA3; Fatty acid desaturase; Membrane-bound 9 desaturase; Stearoyl-CoA desaturase; Stearoyl-coenzyme A (Delta9) desaturase; SCD
Target Type	Successful
Gene Name	SCD
Biochemical Class	Oxidoreductases acting on paired donors
UniProt ID	ACOD_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Type 2 diabetes
Example drug	MK-8245			Phase 2	[522582], [1572592]
Tissue	Liver tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.20 Z-score: 0.54 P-value: 4.73E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 522582	ClinicalTrials.gov (NCT00846391) A Study to Assess the Safety and Efficacy of MK8245 in Patients With Type 2 Diabetes Mellitus and Inadequate Glycemic Control (MK8245-005 AM2). U.S. National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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