Target General Information
Target ID	T16340
Target Name	Interleukin-1 alpha
Synonyms	Hematopoietin1; IL1 alpha; Interleukin1 alpha; IL1A
Target Type	Clinical Trial
Gene Name	IL1A
Biochemical Class	Cytokine: interleukin
UniProt ID	IL1A_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Osteoarthritis
Example drug	ABT-981			Phase 2	[889392], [889410], [1572592]
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.06 Z-score: 0.18 P-value: 4.46E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Rheumatoid arthritis
Example drug	IX207-887			Discontinued in Phase 2	[545177], [1572592]
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.11 Z-score: 0.40 P-value: 4.82E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Arteriosclerosis
Example drug	IL1aQb			Terminated	[548077], [1572592]
Tissue	Peripheral blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.03 Z-score: -0.14 P-value: 5.89E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Type 2 diabetes
Tissue	Liver tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 1.41E-02 Z-score: 0.09 P-value: 7.52E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref
Ref 545177	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002363)
Ref 548077	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021743)
Ref 889392	ClinicalTrials.gov (NCT02087904) A Phase 2a Study Evaluating the Safety, Efficacy, and Pharmacodynamic Effects of ABT-981 in Patients With Knee Osteoarthritis
Ref 889410	ClinicalTrials.gov (NCT02384538) A Phase 2a Study Evaluating the Safety and Efficacy of ABT-981 in Patients With Erosive Hand Osteoarthritis
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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