Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T18876 | ||||
| Target Name | Prostaglandin E2 receptor EP4 | ||||
| Synonyms | EP sub 4 receptor; PGE receptor, EP4 subtype; Prostanoid EP4 receptor; PTGER4 | ||||
| Target Type | Clinical Trial | ||||
| Gene Name | PTGER4 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | PE2R4_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Asthma | ||||
| Example drug | ONO-AE1-437 | Phase 2 | [543189], [1572592] | ||
| Tissue | Nasal and bronchial airway | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.29 Z-score: -0.55 P-value: 4.39E-03 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Osteoarthritis | ||||
| Example drug | EP4-R antagonist | Phase 1 | [549532], [1572592] | ||
| Tissue | Synovial tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.05 Z-score: -0.10 P-value: 5.27E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Ulcerative colitis | ||||
| Tissue | Colon mucosal tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: -0.07 Z-score: -0.22 P-value: 1.94E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of the persons with other diseases not directly affecting the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| Ref 549532 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800039864) | ||||
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