Target General Information
Target ID T27889
Target Name Angiotensin-converting enzyme 2
Synonyms ACEH; ACErelated carboxypeptidase; Angiotensinconverting enzyme 2; Angiotensinconverting enzyme homolog; Metalloprotease MPROT15; Processed angiotensinconverting enzyme 2; ACE2
Target Type Clinical Trial
Gene Name ACE2
Biochemical Class Peptidase
UniProt ID ACE2_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Type 2 diabetes
Example drug MLN4760 Discontinued in Phase 1 [542794], [547469], [1572592]
Tissue Liver tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.40
Z-score: 1.10
P-value: 3.93E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 547469Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016663)
Ref 542794(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7866).
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.