Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T28265 | ||||
| Target Name | Alpha-1-antitrypsin | ||||
| Synonyms | Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Alpha1-proteinase; PRO0684/PRO2209; SERPINA1 | ||||
| Target Type | Successful | ||||
| Gene Name | SERPINA1 | ||||
| Biochemical Class | Serpin family | ||||
| UniProt ID | A1AT_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Chronic obstructive pulmonary disease | ||||
| Example drug | Alphagen | Phase 1 | [536223], [1572592] | ||
| Tissue | Lung tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.08 Z-score: -0.10 P-value: 7.84E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Chronic obstructive pulmonary disease | ||||
| Example drug | Alphagen | Phase 1 | [536223], [1572592] | ||
| Tissue | Small airway epithelium | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.33 Z-score: 0.54 P-value: 1.32E-03 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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