Target General Information
Target ID T29879
Target Name Integrin alpha-5
Synonyms CD49e antigen; FNRA; Fibronectin receptor subunit alpha; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; Integrin alpha-F; VLA-5; ITGA5
Target Type Clinical Trial
Gene Name ITGA5
Biochemical Class Integrin
UniProt ID ITA5_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Asthma
Example drug TR-14531 Discontinued in Phase 1 [547054], [1572592]
Tissue Nasal and bronchial airway
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.19
Z-score: 0.25
P-value: 2.32E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Multiple sclerosis
Example drug ZD-7349 Discontinued in Phase 1 [546708], [1572592]
Tissue Spinal cord
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: -0.07
Z-score: -0.59
P-value: 2.73E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 546708Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009742)
Ref 547054Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012564)
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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