Target General Information
Target ID	T50912
Target Name	Activation B7-2 antigen
Synonyms	Activation B7-2 antigen; B70; BU63; CD28LG2; CTLA-4 counter-receptor B7.2; FUN-1; CD86
Target Type	Successful
Gene Name	CD86
Biochemical Class	Immunoglobulin
UniProt ID	CD86_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Rheumatoid arthritis
Example drug	Abatacept			Approved	[536737], [541949], [1572592]
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.26 Z-score: -0.28 P-value: 6.39E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 541949	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6891).
Ref 536737	Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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