TTD | Expression Details

Target General Information
Target ID	T53524
Target Name	PDGF receptor alpha
Synonyms	CD140a antigen; PDGF-R-alpha; Platelet-derived growth factor receptor alpha; PDGFRA
Target Type	Successful
Gene Name	PDGFRA
Biochemical Class	Kinase
UniProt ID	PGFRA_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Gastric cancer
Example drug	CP-868596	Phase 3	[542807], [547352], [1572592]
Tissue	Gastric tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.23 Z-score: -1.55 P-value: 3.46E-01
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section	Fold-change: -0.16 Z-score: -0.73 P-value: 1.75E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section Download target gene expression data in the tissue of healthy individual
Disease	Glioma
Example drug	MEDI-575	Phase 2	[551134], [1572592]
Tissue	Brainstem tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 1.37 Z-score: 3.31 P-value: 4.48E-02
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Glioma
Example drug	MEDI-575	Phase 2	[551134], [1572592]
Tissue	White matter
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 2.15 Z-score: 1.46 P-value: 9.98E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Ovarian cancer
Example drug	Olaratumab	Phase 1	[889440], [1572592]
Tissue	Ovarian tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -1.66 Z-score: -1.59 P-value: 1.31E-03
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section	Fold-change: -0.74 Z-score: -1.97 P-value: 1.14E-05
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section Download target gene expression data in the tissue of healthy individual
Disease	Renal cancer
Tissue	Kidney
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.38 Z-score: -1.26 P-value: 1.48E-03
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section	Fold-change: -0.12 Z-score: -0.62 P-value: 9.43E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref
Ref 547352	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015430)
Ref 542807	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7882).
Ref 551134	Clinical pipeline report, company report or official report of MedImmune (2011).
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.
Ref 889440	2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. doi: 10.1038/nrd.2017.14.

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Target expression details

Prof. Yuzong CHEN

Prof. Feng ZHU