Target expression details
Target General Information | |||||
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Target ID | T58454 | ||||
Target Name | Fibroblast growth factor receptor 2 | ||||
Synonyms | FGF-2 receptor; FGFR-2; Keratinocyte growth factor receptor 2; FGFR2 | ||||
Target Type | Successful | ||||
Gene Name | FGFR2 | ||||
Biochemical Class | Kinase | ||||
UniProt ID | FGFR2_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Periodontal disease | ||||
Example drug | Trafermin | Phase 3 | [536297], [1572592] | ||
Tissue | Gingival tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: -0.12 Z-score: -0.54 P-value: 5.35E-06 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
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Disease | Alzheimer's disease | ||||
Example drug | MK-2461 | Phase 1/2 | [530708], [1572592] | ||
Tissue | Entorhinal cortex | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.03 Z-score: -0.20 P-value: 4.82E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Retinoblastoma tumor | ||||
Example drug | PD-0183812 | Terminated | [547217], [1572592] | ||
Tissue | Uvea | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 1.08E-03 Z-score: 6.61E-03 P-value: 9.74E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Interstitial cystitis | ||||
Tissue | Bladder tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.05 Z-score: -0.39 P-value: 6.15E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
Reference | |||||
Ref 547217 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014130) |
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