Target General Information
Target ID	T63484
Target Name	Glucose-6-phosphate dehydrogenase
Synonyms	G6PD
Target Type	Clinical Trial
Gene Name	G6PD
Biochemical Class	Short-chain dehydrogenases reductases
UniProt ID	G6PD_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Chronic obstructive pulmonary disease
Example drug	Prasterone			Phase 3	[527619], [1572592]
Tissue	Lung tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.18 Z-score: -0.30 P-value: 4.01E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Chronic obstructive pulmonary disease
Example drug	Prasterone			Phase 3	[527619], [1572592]
Tissue	Small airway epithelium
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.44 Z-score: 0.60 P-value: 2.39E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Rheumatoid arthritis
Example drug	CBF-BS2			Discontinued in Phase 2	[546290], [1572592]
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 2.13 Z-score: 4.86 P-value: 7.05E-07
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 546290	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007279)
Ref 527619	Direct agonist/antagonist functions of dehydroepiandrosterone. Endocrinology. 2005 Nov;146(11):4568-76. Epub 2005 Jun 30.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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