Target expression details
Target General Information | |||||
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Target ID | T92687 | ||||
Target Name | Hydrogen potassium ATPase | ||||
Target Type | Successful | ||||
Gene Name | ATP4A | ||||
Biochemical Class | Hydrolases (EC:3) | ||||
UniProt ID | ATP4A_HUMAN||ATP4B_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Eosinophilic gastritis | ||||
Example drug | AZD-0865 | Phase 2 | [521710], [1572592] | ||
Tissue | Gastric antrum tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: -0.88 Z-score: -0.44 P-value: 7.17E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
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Disease | Ulcerative colitis | ||||
Example drug | LEMINOPRAZOLE | Discontinued in Preregistration | [544691], [1572592] | ||
Tissue | Colon mucosal tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: 0.08 Z-score: 0.38 P-value: 2.18E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of the persons with other diseases not directly affecting the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
Reference | |||||
Ref 544691 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000604) |
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