Target General Information
Target ID T98896
Target Name A disintegrin and metalloproteinase with thrombospondin motifs 5
Synonyms ADAMTS-5; A disintegrin and metalloproteinase with thrombospondinmotifs 5; ADAM-TS 11; ADAM-TS 5; ADAM-TS5; ADMP-2; Aggrecanase-2; ADAMTS5
Target Type Clinical Trial
Gene Name ADAMTS5
Biochemical Class Peptidase
UniProt ID ATS5_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Osteoarthritis
Example drug AGG-523 Phase 1 [521997], [1572592]
Tissue Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.24
Z-score: 0.26
P-value: 6.40E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 521997ClinicalTrials.gov (NCT00454298) Study Evaluating AGG-523 in Subjects With Severe Osteoarthritis Requiring Total Knee Replacement. U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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