Target Information
Target General Infomation | |||||
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Target ID |
T01851
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Former ID |
TTDC00148
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Target Name |
Integrin beta-1
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Gene Name |
ITGB1
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Synonyms |
Beta(1) integrin; CD29 antigen; Fibronectin receptor beta subunit; Integrin VLA-4 beta subunit; ITGB1
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Target Type |
Clinical Trial
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Disease | Macular degeneration [ICD9: 362.5; ICD10: H35.3] | ||||
Non-small cell lung cancer [ICD10: C33-C34] | |||||
Function |
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen, and integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence g-f-p-g-e-r in collagen.
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BioChemical Class |
Integrin
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Target Validation |
T01851
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UniProt ID | |||||
Sequence |
MNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGMPT
SARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLV LRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDF RIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGKQR ISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQ CHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTL SANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNISI GDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEG NGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRK RDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCE ASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDT CTQECSYFNITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVEN PECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGEN PIYKSAVTTVVNPKYEGK |
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Structure |
1K11; 1LHA; 3G9W; 3T9K; 3VI3; 3VI4; 4DX9; 4WJK; 4WK0; 4WK2; 4WK4
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Drugs and Mode of Action | |||||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | Rap1 signaling pathway | ||||
Phagosome | |||||
PI3K-Akt signaling pathway | |||||
Axon guidance | |||||
Focal adhesion | |||||
ECM-receptor interaction | |||||
Cell adhesion molecules (CAMs) | |||||
Platelet activation | |||||
Leukocyte transendothelial migration | |||||
Regulation of actin cytoskeleton | |||||
Bacterial invasion of epithelial cells | |||||
Pathogenic Escherichia coli infection | |||||
Shigellosis | |||||
Pertussis | |||||
Leishmaniasis | |||||
Toxoplasmosis | |||||
Pathways in cancer | |||||
Proteoglycans in cancer | |||||
Small cell lung cancer | |||||
Hypertrophic cardiomyopathy (HCM) | |||||
Arrhythmogenic right ventricular cardiomyopathy (ARVC) | |||||
Dilated cardiomyopathy | |||||
PANTHER Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | ||||
Integrin signalling pathway | |||||
CCKR signaling map ST | |||||
Pathway Interaction Database | Signaling events mediated by PRL | ||||
RhoA signaling pathway | |||||
Beta1 integrin cell surface interactions | |||||
Integrin family cell surface interactions | |||||
Arf6 trafficking events | |||||
Reelin signaling pathway | |||||
Signaling events mediated by TCPTP | |||||
Angiopoietin receptor Tie2-mediated signaling | |||||
Alpha9 beta1 integrin signaling events | |||||
CXCR4-mediated signaling events | |||||
Plexin-D1 Signaling | |||||
Syndecan-4-mediated signaling events | |||||
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | |||||
a4b7 Integrin signaling | |||||
a6b1 and a6b4 Integrin signaling | |||||
Syndecan-2-mediated signaling events | |||||
Validated targets of C-MYC transcriptional repression | |||||
VEGFR3 signaling in lymphatic endothelium | |||||
Alpha4 beta1 integrin signaling events | |||||
Signaling events mediated by focal adhesion kinase | |||||
Reactome | Elastic fibre formation | ||||
Fibronectin matrix formation | |||||
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | |||||
Cell surface interactions at the vascular wall | |||||
Basigin interactions | |||||
Molecules associated with elastic fibres | |||||
Integrin cell surface interactions | |||||
Laminin interactions | |||||
Syndecan interactions | |||||
ECM proteoglycans | |||||
Other semaphorin interactions | |||||
Localization of the PINCH-ILK-PARVIN complex to focal adhesions | |||||
CHL1 interactions | |||||
RHO GTPases Activate Formins | |||||
Platelet Adhesion to exposed collagen | |||||
WikiPathways | TGF beta Signaling Pathway | ||||
Signaling of Hepatocyte Growth Factor Receptor | |||||
Focal Adhesion | |||||
Organogenesis (Part 2 of 3) | |||||
Extracellular matrix organization | |||||
Elastic fibre formation | |||||
Nanoparticle-mediated activation of receptor signaling | |||||
JAK/STAT | |||||
Primary Focal Segmental Glomerulosclerosis FSGS | |||||
Pathogenic Escherichia coli infection | |||||
Arrhythmogenic Right Ventricular Cardiomyopathy | |||||
Neural Crest Differentiation | |||||
Semaphorin interactions | |||||
Platelet Adhesion to exposed collagen | |||||
Integrin-mediated Cell Adhesion | |||||
L1CAM interactions | |||||
Integrin cell surface interactions | |||||
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | |||||
Cell surface interactions at the vascular wall | |||||
Cell junction organization | |||||
References | |||||
Ref 525536 | Bioorg Med Chem Lett. 1999 Jul 5;9(13):1807-12.Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model. | ||||
Ref 529125 | J Med Chem. 2007 Nov 29;50(24):5878-81. Epub 2007 Nov 1.Multiple N-methylation by a designed approach enhances receptor selectivity. | ||||
Ref 530343 | Bioorg Med Chem Lett. 2009 Oct 1;19(19):5803-6. Epub 2009 Jul 28.Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist. | ||||
Ref 532756 | Radretumab radioimmunotherapy in patients with brain metastasis: a 124I-L19SIP dosimetric PET study. Cancer Immunol Res. 2013 Aug;1(2):134-43. | ||||
Ref 536198 | Suppression and regression of choroidal neovascularization by systemic administration of an alpha5beta1 integrin antagonist. Mol Pharmacol. 2006 Jun;69(6):1820-8. Epub 2006 Mar 9. |
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