Target General Infomation |
Target ID |
T47387
|
Former ID |
TTDI02260
|
Target Name |
mRNA of BCL-2
|
Gene Name |
BCL2
|
Synonyms |
Apoptosis regulator Bcl2 (mRNA); BCL2 (mRNA); BCL2
|
Target Type |
Clinical Trial
|
Function |
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
|
BioChemical Class |
Target of antisense drug
|
UniProt ID |
|
Sequence |
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
|
Drugs and Mode of Action |
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) |
Pathways |
References |
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