Target Information
Target General Infomation | |||||
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Target ID |
T54779
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Former ID |
TTDI02259
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Target Name |
mRNA of Ribonucleotide reductase R2 component
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Gene Name |
RRM2
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Synonyms |
RRM2 (mRNA); Ribonucleoside-diphosphate reductase subunit M2 (mRNA); Ribonucleotide reductasesmall chain (mRNA); Ribonucleotide reductasesmall subunit (mRNA); RRM2
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Target Type |
Research
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Function |
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
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BioChemical Class |
Target of siRNA drug
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UniProt ID | |||||
EC Number |
EC 1.17.4.1
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Sequence |
MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKT
KAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLI DTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIE QEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTN FFEKRVGEYQRMGVMSSPTENSFTLDADF |
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Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
BioCyc Pathway | Pyrimidine deoxyribonucleotides biosynthesis from CTP | ||||
Pyrimidine deoxyribonucleotides de novo biosynthesis | |||||
Guanosine nucleotides de novo biosynthesis | |||||
Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis | |||||
Superpathway of purine nucleotide salvage | |||||
Purine nucleotides de novo biosynthesis | |||||
Adenosine deoxyribonucleotides de novo biosynthesis | |||||
Guanosine deoxyribonucleotides de novo biosynthesis | |||||
KEGG Pathway | Purine metabolism | ||||
Pyrimidine metabolism | |||||
Glutathione metabolism | |||||
Metabolic pathways | |||||
p53 signaling pathway | |||||
NetPath Pathway | EGFR1 Signaling Pathway | ||||
PANTHER Pathway | p53 pathway | ||||
De novo purine biosynthesis | |||||
De novo pyrimidine deoxyribonucleotide biosynthesis | |||||
Pathway Interaction Database | E2F transcription factor network | ||||
PathWhiz Pathway | Purine Metabolism | ||||
Pyrimidine Metabolism | |||||
Reactome | E2F mediated regulation of DNA replication | ||||
G1/S-Specific Transcription | |||||
WikiPathways | Nucleotide Metabolism | ||||
Retinoblastoma (RB) in Cancer | |||||
Metabolism of nucleotides | |||||
Fluoropyrimidine Activity |
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