Target Information
Target General Infomation | |||||
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Target ID |
T56308
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Former ID |
TTDR00519
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Target Name |
Interleukin-11
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Gene Name |
IL11
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Synonyms |
AGIF; Adipogenesis inhibitory factor; IL-11; Oprelvekin; IL11
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Target Type |
Clinical Trial
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Disease | Thrombocytopenia [ICD9: 287.3, 287.4, 287.5; ICD10: D69.6, P61.0] | ||||
Function |
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.
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BioChemical Class |
Cytokine: interleukin
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UniProt ID | |||||
Sequence |
MNCVCRLVLVVLSLWPDTAVAPGPPPGPPRVSPDPRAELDSTVLLTRSLLADTRQLAAQL
RDKFPADGDHNLDSLPTLAMSAGALGALQLPGVLTRLRADLLSYLRHVQWLRRAGGSSLK TLEPELGTLQARLDRLLRRLQLLMSRLALPQPPPDPPAPPLAPPSSAWGGIRAAHAILGG LHLTLDWAVRGLLLLKTRL |
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Drugs and Mode of Action | |||||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | Cytokine-cytokine receptor interaction | ||||
Jak-STAT signaling pathway | |||||
Hematopoietic cell lineage | |||||
Rheumatoid arthritis | |||||
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
PANTHER Pathway | Interleukin signaling pathway | ||||
WikiPathways | Cytokines and Inflammatory Response | ||||
Differentiation Pathway | |||||
Integrated Pancreatic Cancer Pathway | |||||
Interleukin-11 Signaling Pathway | |||||
References |
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