Target General Infomation
Target ID
T56308
Former ID
TTDR00519
Target Name
Interleukin-11
Gene Name
IL11
Synonyms
AGIF; Adipogenesis inhibitory factor; IL-11; Oprelvekin; IL11
Target Type
Clinical Trial
Disease Thrombocytopenia [ICD9: 287.3, 287.4, 287.5; ICD10: D69.6, P61.0]
Function
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.
BioChemical Class
Cytokine: interleukin
UniProt ID
Sequence
MNCVCRLVLVVLSLWPDTAVAPGPPPGPPRVSPDPRAELDSTVLLTRSLLADTRQLAAQL
RDKFPADGDHNLDSLPTLAMSAGALGALQLPGVLTRLRADLLSYLRHVQWLRRAGGSSLK
TLEPELGTLQARLDRLLRRLQLLMSRLALPQPPPDPPAPPLAPPSSAWGGIRAAHAILGG
LHLTLDWAVRGLLLLKTRL
Drugs and Mode of Action
Drug(s) VM-501 Drug Info Phase 3 Thrombocytopenia [549158]
Agonist VM-501 Drug Info [549159]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Hematopoietic cell lineage
Rheumatoid arthritis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Interleukin signaling pathway
WikiPathways Cytokines and Inflammatory Response
Differentiation Pathway
Integrated Pancreatic Cancer Pathway
Interleukin-11 Signaling Pathway
References
Ref 549158Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033052)
Ref 549159Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033052)

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