Target Information
Target General Infomation | |||||
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Target ID |
T82051
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Former ID |
TTDI02325
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Target Name |
mRNA of p53
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Gene Name |
TP53
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Synonyms |
Antigen NYCO13 (mRNA); Cellular tumor antigen p53 (mRNA); Phosphoprotein p53 (mRNA); TP53 (mRNA); Tumor suppressor p53 (mRNA); TP53
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Target Type |
Clinical Trial
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Disease | Acute myeloid leukemia [ICD9: 205; ICD10: C92.0] | ||||
Hearing disorder [ICD10: H90.5] | |||||
Function |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stoppingcell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1- mediated transcriptional activation of PER2 (PubMed:24051492). {ECO:0000269|PubMed:11025664, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15340061, ECO:0000269|PubMed:17317671, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:24051492, ECO:0000269|PubMed:9840937}.
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BioChemical Class |
Target of siRNA drug
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UniProt ID | |||||
Sequence |
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP
DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD |
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Drugs and Mode of Action | |||||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | MAPK signaling pathway | ||||
Sphingolipid signaling pathway | |||||
Cell cycle | |||||
p53 signaling pathway | |||||
PI3K-Akt signaling pathway | |||||
Apoptosis | |||||
Wnt signaling pathway | |||||
Neurotrophin signaling pathway | |||||
Thyroid hormone signaling pathway | |||||
Amyotrophic lateral sclerosis (ALS) | |||||
Huntington' | |||||
s disease | |||||
Hepatitis C | |||||
Hepatitis B | |||||
Measles | |||||
HTLV-I infection | |||||
Herpes simplex infection | |||||
Epstein-Barr virus infection | |||||
Pathways in cancer | |||||
Transcriptional misregulation in cancer | |||||
Viral carcinogenesis | |||||
Proteoglycans in cancer | |||||
MicroRNAs in cancer | |||||
Colorectal cancer | |||||
Pancreatic cancer | |||||
Endometrial cancer | |||||
Glioma | |||||
Prostate cancer | |||||
Thyroid cancer | |||||
Basal cell carcinoma | |||||
Melanoma | |||||
Bladder cancer | |||||
Chronic myeloid leukemia | |||||
Small cell lung cancer | |||||
Non-small cell lung cancer | |||||
Central carbon metabolism in cancer | |||||
NetPath Pathway | FSH Signaling Pathway | ||||
PANTHER Pathway | Apoptosis signaling pathway | ||||
Huntington disease | |||||
Wnt signaling pathway | |||||
p53 pathway | |||||
P53 pathway feedback loops 1 | |||||
p53 pathway by glucose deprivation | |||||
p53 pathway feedback loops 2 | |||||
Pathway Interaction Database | Signaling events mediated by HDAC Class III | ||||
Validated targets of C-MYC transcriptional activation | |||||
LKB1 signaling events | |||||
Glucocorticoid receptor regulatory network | |||||
Direct p53 effectors | |||||
p75(NTR)-mediated signaling | |||||
AP-1 transcription factor network | |||||
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | |||||
Signaling mediated by p38-alpha and p38-beta | |||||
Aurora A signaling | |||||
BARD1 signaling events | |||||
p53 pathway | |||||
PLK3 signaling events | |||||
Reactome | Activation of NOXA and translocation to mitochondria | ||||
Activation of PUMA and translocation to mitochondria | |||||
Pre-NOTCH Transcription and Translation | |||||
Oxidative Stress Induced Senescence | |||||
Formation of Senescence-Associated Heterochromatin Foci (SAHF) | |||||
Oncogene Induced Senescence | |||||
DNA Damage/Telomere Stress Induced Senescence | |||||
Autodegradation of the E3 ubiquitin ligase COP1 | |||||
TP53 Regulates Metabolic Genes | |||||
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | |||||
Stabilization of p53 | |||||
Factors involved in megakaryocyte development and platelet production | |||||
WikiPathways | DNA Damage Response (only ATM dependent) | ||||
DNA Damage Response | |||||
ErbB Signaling Pathway | |||||
Senescence and Autophagy in Cancer | |||||
G1 to S cell cycle control | |||||
Sandbox Pathway | |||||
Wnt Signaling Pathway and Pluripotency | |||||
TGF beta Signaling Pathway | |||||
Copper homeostasis | |||||
Bladder Cancer | |||||
Mammary gland development pathway - Involution (Stage 4 of 4) | |||||
Pre-NOTCH Expression and Processing | |||||
Apoptosis | |||||
ATM Signaling Pathway | |||||
Amyotrophic lateral sclerosis (ALS) | |||||
Retinoblastoma (RB) in Cancer | |||||
Spinal Cord Injury | |||||
Integrated Pancreatic Cancer Pathway | |||||
Oncostatin M Signaling Pathway | |||||
Gastric cancer network 2 | |||||
Prostate Cancer | |||||
Signaling Pathways in Glioblastoma | |||||
Metastatic brain tumor | |||||
Alzheimers Disease | |||||
Integrated Breast Cancer Pathway | |||||
Integrated Cancer pathway | |||||
Intrinsic Pathway for Apoptosis | |||||
Factors involved in megakaryocyte development and platelet production | |||||
Cell Cycle | |||||
Cell Cycle Checkpoints | |||||
Apoptosis Modulation and Signaling | |||||
Folate Metabolism | |||||
TP53 Network | |||||
Fluoropyrimidine Activity | |||||
miRNAs involved in DNA damage response | |||||
miRNA Regulation of DNA Damage Response | |||||
AMPK Signaling | |||||
References |
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