Target Information
Target General Infomation | |||||
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Target ID |
T01908
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Former ID |
TTDC00028
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Target Name |
Tissue kallikrein
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Gene Name |
KLK2
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Synonyms |
Glandular kallikrein; KLK; Kallikrein; hGK; KLK2
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Target Type |
Discontinued
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Disease | Atopic dermatitis [ICD9: 691.8, 692.9; ICD10: L00-L99] | ||||
Function |
Glandular kallikreins cleave Met-Lys andArg-Ser bonds in kininogen to release Lys-bradykinin.
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BioChemical Class |
Peptidase
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Target Validation |
T01908
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UniProt ID | |||||
EC Number |
EC 3.4.21.35
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Sequence |
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWV
LTAAHCLKKNSQVWLGRHNLFEPEDTGQRVPVSHSFPHPLYNMSLLKHQSLRPDEDSSHD LMLLRLSEPAKITDVVKVLGLPTQEPALGTTCYASGWGSIEPEEFLRPRSLQCVSLHLLS NDMCARAYSEKVTEFMLCAGLWTGGKDTCGGDSGGPLVCNGVLQGITSWGPEPCALPEKP AVYTKVVHYRKWIKDTIAANP |
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Structure |
4NFE; 4NFF
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Drugs and Mode of Action | |||||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | Endocrine and other factor-regulated calcium reabsorption | ||||
NetPath Pathway | IL2 Signaling Pathway | ||||
Pathway Interaction Database | Coregulation of Androgen receptor activity | ||||
Regulation of Androgen receptor activity | |||||
Reactome | Activation of Matrix Metalloproteinases | ||||
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | |||||
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | |||||
WikiPathways | Prostate Cancer | ||||
References | |||||
Ref 528079 | Novel peptide inhibitors of human kallikrein 2. J Biol Chem. 2006 May 5;281(18):12555-60. Epub 2006 Mar 9. | ||||
Ref 536840 | Bioreactor strategies for improving production yield and functionality of a recombinant human protein in transgenic tobacco cell cultures. Biotechnol Bioeng. 2009 Feb 1;102(2):508-20. | ||||
Ref 537435 | Optimization of the bioprocessing conditions for scale-up of transient production of a heterologous protein in plants using a chemically inducible viral amplicon expression system. Biotechnol Prog. 2009 May-Jun;25(3):722-34. |
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