Target Information

Target General Infomation
Target ID
T03896
Target Name
Hepatitis C virus serine protease NS3/4A
Target Type
Successful
Disease Chronic HCV infection [ICD9: 070.4, 070.5, 070.70; ICD10: B17.1, B18.2]
HCV infection [ICD9: 070.4, 070.5, 070.70; ICD10: B17.1, B18.2]
BioChemical Class
Hydrolases (EC:3)
UniProt ID
P26664 (1027-1657)||P26664 (1658-1711)
EC Number
EC 3.6.1.15
Drugs and Mode of Action
Drug(s) BOCEPREVIR Drug Info Approved HCV infection [531783], [542802]
Simeprevir Drug Info Approved Chronic HCV infection [542389], [551871]
Telaprevir Drug Info Approved HCV infection [531783], [542797]
Modulator BOCEPREVIR Drug Info [531783]
Simeprevir Drug Info [532651]
Telaprevir Drug Info [531783]
References
Ref 5317832011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
Ref 542389(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7367).
Ref 542797(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7871).
Ref 542802(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7876).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 5317832011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
Ref 5326512013 FDA drug approvals. Nat Rev Drug Discov. 2014 Feb;13(2):85-9.

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