Target Information

Target General Infomation
Target ID
T15700
Former ID
TTDR00433
Target Name
Caspase-8
Gene Name
CASP8
Synonyms
Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/CED-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MACH; MORT1-associated CED-3 homolog; CASP8
Target Type
Research
Disease Autoimmune diabetes [ICD10: E08-E13]
Cancer [ICD9: 140-229; ICD10: C00-C96]
Function
Most upstream protease of the activation cascade of caspases responsible for the tnfrsf6/fas mediated and tnfrsf1a induced cell death. Binding to the adapter molecule fadd recruits it to either receptor.
BioChemical Class
Peptidase
UniProt ID
Q14790
EC Number
EC 3.4.22.61
Sequence
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Structure
1F9E; 1I4E; 1QDU; 1QTN; 2C2Z; 2FUN; 2K7Z; 2Y1L; 3H11; 3KJN; 3KJQ; 4JJ7
Inhibitor Acetyl-Ile-Glu-Thr-Asp-aldehyde Drug Info [534905]
Amooranin Drug Info [532688]
Modulator Glionitrin A Drug Info [532688]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
DRM DRM Info
Pathways
KEGG Pathway p53 signaling pathway
Apoptosis
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
TNF signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer&#039
s disease
Huntington&#039
Legionellosis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis B
Herpes simplex infection
Pathways in cancer
Viral carcinogenesis
Viral myocarditis
PANTHER Pathway Apoptosis signaling pathway
FAS signaling pathway
Huntington disease
Pathway Interaction Database Coregulation of Androgen receptor activity
TRAIL signaling pathway
FAS (CD95) signaling pathway
TNF receptor signaling pathway
Ceramide signaling pathway
Integrins in angiogenesis
Negative effector of Fas and TNF-alpha
Caspase Cascade in Apoptosis
Reactome Apoptotic cleavage of cellular proteins
Ligand-dependent caspase activation
NOD1/2 Signaling Pathway
TRIF-mediated programmed cell death
Caspase-mediated cleavage of cytoskeletal proteins
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
CLEC7A/inflammasome pathway
Regulation of necroptotic cell death
Dimerization of procaspase-8
FasL/ CD95L signaling
TRAIL signaling
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
WikiPathways Toll-like receptor signaling pathway
DNA Damage Response
Apoptosis Modulation by HSP70
FAS pathway and Stress induction of HSP regulation
MyD88-independent cascade
Apoptosis
Nanoparticle triggered regulated necrosis
Integrated Pancreatic Cancer Pathway
Parkin-Ubiquitin Proteasomal System pathway
Allograft Rejection
AGE/RAGE pathway
TNF alpha Signaling Pathway
Prostate Cancer
Alzheimers Disease
TWEAK Signaling Pathway
Integrated Breast Cancer Pathway
Integrated Cancer pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Intrinsic Pathway for Apoptosis
Extrinsic Pathway for Apoptosis
Apoptotic execution phase
Apoptosis Modulation and Signaling
miRNA Regulation of DNA Damage Response
Regulation of toll-like receptor signaling pathway
NOD pathway
References
Ref 532688Glionitrin A, a new diketopiperazine disulfide, activates ATM-ATR-Chk1/2 via 53BP1 phosphorylation in DU145 cells and shows antitumor effect in xenograft model. Biol Pharm Bull. 2014;37(3):378-86.
Ref 534905The atomic-resolution structure of human caspase-8, a key activator of apoptosis. Structure. 1999 Sep 15;7(9):1135-43.

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