Target Information

Target General Infomation
Target ID
T16888
Former ID
TTDI02036
Target Name
Eotaxin ligand
Gene Name
CCL11
Synonyms
CC motif chemokine 11; Eosinophil chemotactic protein; Eotaxin; Smallinducible cytokine A11; CCL11
Target Type
Clinical Trial
Disease Ocular allergy [ICD9: 360-379; ICD10: H00-H59]
Function
In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.
BioChemical Class
Cytokine: CC chemokine
UniProt ID
P51671
Sequence
MKVSAALLWLLLIAAAFSPQGLAGPASVPTTCCFNLANRKIPLQRLESYRRITSGKCPQK
AVIFKTKLAKDICADPKKKWVQDSMKYLDQKSPTPKP
Drugs and Mode of Action
Drug(s) Bertilimumab Drug Info Phase 2 Ocular allergy [536119]
Modulator Bertilimumab Drug Info [1572591]
References
Ref 536119Emerging drugs for ocular allergy. Expert Opin Emerg Drugs. 2005 Aug;10(3):505-20.
Ref
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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