Target Information
Target General Infomation | |||||
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Target ID |
T25927
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Former ID |
TTDR01396
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Target Name |
mRNA of human caspase 6
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Gene Name |
CASP6
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Synonyms |
Apoptotic protease Mch2 (mRNA); CASP6 (mRNA); Caspase6 (mRNA); Caspase6 subunit p11 (mRNA); CASP6
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Target Type |
Research
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Function |
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
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BioChemical Class |
Peptidase
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Target Validation |
T25927
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UniProt ID | |||||
EC Number |
EC 3.4.22.59
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Sequence |
MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLT
LPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLS HGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDN QTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYG SSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN |
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Pathways | |||||
KEGG Pathway | Apoptosis | ||||
NetPath Pathway | TCR Signaling Pathway | ||||
PANTHER Pathway | FAS signaling pathway | ||||
Pathway Interaction Database | Direct p53 effectors | ||||
p75(NTR)-mediated signaling | |||||
C-MYB transcription factor network | |||||
Negative effector of Fas and TNF-alpha | |||||
Caspase Cascade in Apoptosis | |||||
Reactome | Apoptotic cleavage of cellular proteins | ||||
Caspase-mediated cleavage of cytoskeletal proteins | |||||
WikiPathways | Apoptosis Modulation by HSP70 | ||||
FAS pathway and Stress induction of HSP regulation | |||||
Apoptosis | |||||
Parkinsons Disease Pathway | |||||
Apoptotic execution phase | |||||
Apoptosis Modulation and Signaling | |||||
References | |||||
Ref 528057 | J Med Chem. 2006 Mar 9;49(5):1613-23.Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. |
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