Target General Infomation
Target ID
T25927
Former ID
TTDR01396
Target Name
mRNA of human caspase 6
Gene Name
CASP6
Synonyms
Apoptotic protease Mch2 (mRNA); CASP6 (mRNA); Caspase6 (mRNA); Caspase6 subunit p11 (mRNA); CASP6
Target Type
Research
Function
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
BioChemical Class
Peptidase
Target Validation
T25927
UniProt ID
EC Number
EC 3.4.22.59
Sequence
MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLT
LPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLS
HGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDN
QTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYG
SSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN
Inhibitor Ac-VEID-CHO Drug Info [530042]
Isoquinoline-1,3,4(2H)-trione Drug Info [528057]
Pathways
KEGG Pathway Apoptosis
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Direct p53 effectors
p75(NTR)-mediated signaling
C-MYB transcription factor network
Negative effector of Fas and TNF-alpha
Caspase Cascade in Apoptosis
Reactome Apoptotic cleavage of cellular proteins
Caspase-mediated cleavage of cytoskeletal proteins
WikiPathways Apoptosis Modulation by HSP70
FAS pathway and Stress induction of HSP regulation
Apoptosis
Parkinsons Disease Pathway
Apoptotic execution phase
Apoptosis Modulation and Signaling
References
Ref 528057J Med Chem. 2006 Mar 9;49(5):1613-23.Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors.
Ref 530042J Med Chem. 2009 Apr 23;52(8):2188-91.Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.
Ref 549657US patent application no. 6,566,135, Antisense modulation of caspase 6 expression.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.