Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T26774
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| Former ID |
TTDR00489
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| Target Name |
Nuclear receptor coactivator 3
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| Gene Name |
NCOA3
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| Synonyms |
ACTR; AIB-1; AIB1 (SRC-3); Amplified in breast cancer-1 protein; CBP-interacting protein; NCoA-3; PCIP; RAC-3; Receptor-associated coactivator 3; SRC-3; Steroid receptor coactivator protein 3; TRAM-1; Thyroid hormone receptor activator molecule 1; NCOA3
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| Target Type |
Research
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| Function |
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex.
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| BioChemical Class |
Acyltransferase
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| Target Validation |
T26774
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| UniProt ID | |||||
| EC Number |
EC 2.3.1.48
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| Sequence |
MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDID
NFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSSTGQGVIDKDSLGPLLLQA LDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNG VSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGE DLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRC IQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDR HGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSSRAYGLA DPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPGLAPNQQNI MISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSLSALQAISEGVGTSLLST LSSPGPKLDNSPNMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKE SSVEGAENQRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVS SSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGN VVKQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQE KDPKIKTETSEEGSGDLDNLDAILGDLTSSDFYNNSISSNGSHLGTKQQVFQGTNSLGLK SSQSVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGS SMGGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSIPT LPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAASNQLGSWPDGMLSMEQV SHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPE LVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNSMMN QMNQQGNFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALELKMENPTA GGAAVMRPMMQPQVSSQQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQ QQQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQ PDPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQSSEMKGWPSGNLARNSSFSQQQ FAHQGNPAVYSMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC |
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| Pathways | |||||
| KEGG Pathway | Thyroid hormone signaling pathway | ||||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | |||||
| Pathway Interaction Database | Validated nuclear estrogen receptor beta network | ||||
| Validated nuclear estrogen receptor alpha network | |||||
| Retinoic acid receptors-mediated signaling | |||||
| FOXA1 transcription factor network | |||||
| Reactome | PPARA activates gene expression | ||||
| Transcriptional regulation of white adipocyte differentiation | |||||
| MAPK6/MAPK4 signaling | |||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| EGF/EGFR Signaling Pathway | |||||
| Nuclear Receptors Meta-Pathway | |||||
| Pregnane X Receptor pathway | |||||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |||||
| Transcriptional Regulation of White Adipocyte Differentiation | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| Integrated Breast Cancer Pathway | |||||
| Androgen receptor signaling pathway | |||||
| References | |||||
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