Target Information

Target General Infomation
Target ID
T33754
Former ID
TTDS00200
Target Name
CGMP-inhibited 3',5'-cyclic phosphodiesterase
Synonyms
CAMP phosphodiesterase III; CGI-PDE; Cyclic AMP phosphodiesterase III; Cyclic GMP inhibited phosphodiesterase; PDE3; Phosphodiesterase 3; Phosphodiesterase III
Target Type
Successful
Disease Congestive heart failure [ICD9: 428; ICD10: I50]
Heart failure [ICD9: 428; ICD10: I50]
BioChemical Class
Phosphoric diester hydrolases
Target Validation
T33754
EC Number
EC 3.1.4.17
Drugs and Mode of Action
Drug(s) Amrinone Drug Info Approved Congestive heart failure [536361], [551871]
Olprinone Drug Info Approved Heart failure [544653], [551871]
Inhibitor Amrinone Drug Info [535488]
Cilostamide Drug Info [535141]
Olprinone Drug Info [535590]
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 544653Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000438)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535141Phosphodiesterase 3 as a potential target for therapy of malignant tumors in the submandibular gland. Anticancer Drugs. 2001 Jan;12(1):79-83.
Ref 535488Effects of amrinone on hepatic ischemia-reperfusion injury in rats. J Hepatol. 2002 Jul;37(1):31-8.
Ref 535590Olprinone: a phosphodiesterase III inhibitor with positive inotropic and vasodilator effects. Cardiovasc Drug Rev. 2002 Fall;20(3):163-74.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.