Target Information
Target General Infomation | |||||
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Target ID |
T81103
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Former ID |
TTDI02255
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Target Name |
mRNA of Caspase-2
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Gene Name |
CASP2
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Synonyms |
CASP2 (mRNA); Caspase2 (mRNA); Caspase2 subunit p12 (mRNA); NEDD2 (mRNA); Neural precursor cell expressed developmentally downregulated protein 2 (mRNA); Protease ICH1 (mRNA); CASP2
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Target Type |
Clinical Trial
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Disease | Glaucoma [ICD9: 365; ICD10: H40-H42] | ||||
Function |
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.
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BioChemical Class |
Target of siRNA drug
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UniProt ID | |||||
EC Number |
EC 3.4.22.55
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Sequence |
MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHL
LEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLT TLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCT PEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDV HVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLF DNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPT RSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGY APGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT |
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Drugs and Mode of Action | |||||
Pathways | |||||
NetPath Pathway | TCR Signaling Pathway | ||||
IL4 Signaling Pathway | |||||
Pathway Interaction Database | Negative effector of Fas and TNF-alpha | ||||
Caspase Cascade in Apoptosis | |||||
Reactome | NOD1/2 Signaling Pathway | ||||
NADE modulates death signalling | |||||
WikiPathways | Apoptosis Modulation by HSP70 | ||||
Apoptosis | |||||
Parkinsons Disease Pathway | |||||
Signalling by NGF | |||||
Apoptosis Modulation and Signaling | |||||
References |
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